This study aimed to examine the effects of parent-adolescent positive communication and academic self-efficacy on adolescents’ motivation of learning. The subjects were 219(83 male, 136 female) students in the 1-3th grade of two middle schools in S City. The data were analyzed using SPSSWIN 23.0 program. The results were as follows: First, mother-adolescent positive communication, father-adolescent positive communication, and academic self-efficacy were positively correlated with motivation of learning. Second, regression analyses showed that father-adolescent positive communication had significant effect on motivation of learning, whereas mother -adolescent positive communication had not. Third, academic self-efficacy had statistically significant effect on motivation of learning. Fourth, stepwise multiple regression analysis results showed that academic self-efficacy, father-adolescent positive communication had a significantly contribution to motivation of learning in order. Finally, the study’s limits and further discussion were suggested.